Multiple Vimpat(R) (lacosamide) Studies Presented At American Epilepsy Society Annual Meeting Part 2

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The studies enmeshed a inclusive of greatest than 1,300 patients, beside 944 randomized to receive Vimpat(R) at one of the three dose (200 mg/day, n=270; 400 mg/day, n=471; 600 mg/day, n=203) and 364 randomized to the placebo discussion group. Patients in the exposure group received Vimpat(R) at 100 mg/day (50 mg double daily) during the pilot week of treatment, haunt via weekly titration in 100 mg/day increment to the arrangement out targeted dose.

This sympathetic group surround be alive with epilepsy all for an norm of almost 24 years. Overall, 77.4 percent of patients had try four or more AEDs in their lifetime and 45.2 percent had tried seven or more. Most patients (84.4 percent) were taking two or three concomitant AEDs at the occasion of analysis opening, largely carbamazepine (35.2 percent), lamotrigine (31.2 percent), levetiracetam (29.0 percent), valproate (23.6 percent), and topiramate (22.3 percent). At baseline, patients report more than two to three times the numeral of seizure per 28 days obligatory by the inclusion benchmark.

A total of 87 percent of patients in the placebo group completed treatment, as do 82 percent, 77 percent, and 62 percent in the 200, 400, and 600 mg/day Vimpat(R) groups.

Summary of Vimpat(R) Data Presented at 2008 AES Annual Meeting Early Onset of Efficacy in the Initial Weeks of Treatment with Lacosamide: A Pooled Analysis of Three Phase II/III Trials This analysis found that Vimpat(R) demonstrated statistically evocative efficacy as precipitate as the original week of treatment, with uniformly significant grades for both primary endpoints starting at doses of 100 mg/day.

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